3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide

Base Information

• Chemical Name: 3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide
• CAS No.: 203925-95-5
• Molecular Formula: C₂₁H₂₁N₅O₄S
• Molecular Weight: 439.495

Synonyms:3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide

Chemical Property of 3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide

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Technology Process of 3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide

There total 3 articles about 3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

benzylamine (100-46-9) + 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine (200011-85-4) → 3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide (203925-95-5)

Guidance literature:

With caesium carbonate; In acetonitrile; at 75 ℃; for 4h;

DOI:10.1016/S0960-894X(98)00386-2

Reference yield:

3-hydroxy-N,N-dimethylbenzamide (15789-03-4) → 3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide (203925-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Cs₂CO₃ / acetonitrile / 0 °C

2: 48 percent / Cs₂CO₃ / acetonitrile / 4 h / 75 °C

With caesium carbonate; In acetonitrile;

DOI:10.1016/S0960-894X(98)00386-2

Reference yield:

4,6-dichloro-2-(methylthio)-5-nitropyrimidine (1979-96-0) → 3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide (203925-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Cs₂CO₃ / acetonitrile / 0 °C

2: 48 percent / Cs₂CO₃ / acetonitrile / 4 h / 75 °C

With caesium carbonate; In acetonitrile;

DOI:10.1016/S0960-894X(98)00386-2

upstream raw materials:

benzylamine

2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine

3-hydroxy-N,N-dimethylbenzamide

4,6-dichloro-2-(methylthio)-5-nitropyrimidine

Downstream raw materials:

3-(6-Benzylamino-2-methanesulfonyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide

2-(2-benzyloxy-5-cyanophenoxy)-4-(benzyl)amino-5-amino-6-(3-dimethylaminocarbonylphenoxy)pyrimidine

3-[9-Benzyl-2-(2-benzyloxy-5-cyano-phenoxy)-8-methyl-9H-purin-6-yloxy]-N,N-dimethyl-benzamide

2-(2-benzyloxy-5-cyanophenoxy)-4-benzylamino-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine

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