2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine

Base Information

• Chemical Name: 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine
• CAS No.: 200011-85-4
• Molecular Formula: C₁₄H₁₃ClN₄O₄S
• Molecular Weight: 368.801

Synonyms:2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine

Chemical Property of 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine

Chemical Property:

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Technology Process of 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine

There total 1 articles about 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-hydroxy-N,N-dimethylbenzamide (15789-03-4) + 4,6-dichloro-2-(methylthio)-5-nitropyrimidine (1979-96-0) → 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine (200011-85-4)

Guidance literature:

With caesium carbonate; In acetonitrile; at 0 ℃;

DOI:10.1016/S0960-894X(98)00386-2

Reference yield: 95.0%

GlyOEt*HCl (459-73-4) + 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine (200011-85-4) → [6-(3-Dimethylcarbamoyl-phenoxy)-2-methylsulfanyl-5-nitro-pyrimidin-4-ylamino]-acetic acid ethyl ester (200011-86-5)

Guidance literature:

With caesium carbonate; In acetonitrile; at 0 ℃; for 2h;

DOI:10.1016/S0960-894X(98)00386-2

Reference yield: 48.0%

ethyl 2-hydroxyacetate (623-50-7) + 2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine (200011-85-4) → 2-methylthio-4-(ethoxycarbonyl)methoxy-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine (200011-87-6)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

3-hydroxy-N,N-dimethylbenzamide

4,6-dichloro-2-(methylthio)-5-nitropyrimidine

Downstream raw materials:

[6-(3-Dimethylcarbamoyl-phenoxy)-2-methylsulfanyl-5-nitro-pyrimidin-4-ylamino]-acetic acid ethyl ester

3-(6-Benzylamino-2-methylsulfanyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide

3-(6-Benzylamino-2-methanesulfonyl-5-nitro-pyrimidin-4-yloxy)-N,N-dimethyl-benzamide

[6-(3-Dimethylcarbamoyl-phenoxy)-2-methanesulfonyl-5-nitro-pyrimidin-4-ylamino]-acetic acid ethyl ester

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