(S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

Base Information

Chemical Name:(S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide
CAS No.:1356336-73-6
Molecular Formula:C₁₇H₁₆ClNO₃S
Molecular Weight:349.838
Hs Code.:

Synonyms:(S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

Suppliers and Price of (S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

Chemical Property:

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Technology Process of (S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

There total 2 articles about (S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1356336-79-2
2-(2-chloroethyl)-4,5-methylenedioxybenzaldehyde

: 188447-91-8
(S)-p-toluenesulfinimide

: 1356336-73-6
(S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

Guidance literature:: With titanium(IV) tetraethanolate; In dichloromethane; for 4h; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.046

Reference yield:

: 6006-82-2
3,4-methylenedioxyphenethyl alcohol

: 1356336-73-6
(S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(IV) chloride / 0 - 25 °C / Inert atmosphere

2.1: acetyl chloride / 4 h / Inert atmosphere; Reflux

2.2: 1 h / 90 - 100 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / dichloromethane / 4 h / Reflux; Inert atmosphere

With titanium(IV) tetraethanolate; tin(IV) chloride; acetyl chloride; In dichloromethane;
DOI:10.1016/j.tet.2011.11.046

Reference yield: 68.0%

: 1356336-70-3
(S)-1,2-dimethoxy-4-methyl-3-(p-tolylsulfinyl)benzene

: 1356336-73-6
(S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide

: 1356336-75-8
(1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-methylenedioxy-2-(S)-p-tolylsulfinyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: (S)-1,2-dimethoxy-4-methyl-3-(p-tolylsulfinyl)benzene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

(S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.046