C₈H₉FOS

Base Information

• Chemical Name: C₈H₉FOS
• CAS No.: 1510440-59-1
• Molecular Formula: C₈H₉FOS
• Molecular Weight: 172.223
• Mol file: 1510440-59-1.mol

Synonyms:C₈H₉FOS

Chemical Property of C₈H₉FOS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈H₉FOS

There total 2 articles about C₈H₉FOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-fluoro-5-(methylthio)benzoic acid (57318-98-6) → C8H9FOS (1510440-59-1)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

p-fluorothioanisole (371-15-3) → C8H9FOS (1510440-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -60 °C

1.2: 3 h / 20 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C

With n-butyllithium; dimethylsulfide borane complex; In tetrahydrofuran;

Reference yield: 85.0%

C8H9FOS (1510440-59-1) → C8H8BrFS (1588424-17-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

p-fluorothioanisole

2-fluoro-5-(methylthio)benzoic acid

Downstream raw materials:

1-ethyl-3-(2-fluoro-5-(methylthio)phenyl)-7-((5-(methyl(1-methylpiperidin-4-yl)amino)pyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

2-(2-fluoro-5-(methylthio)phenyl)acetonitrile

7-chloro-1-ethyl-3-(2-fluoro-5-(methylthio)phenyl)-1,6-naphthyridin-2(1H)-imine

7-chloro-1-ethyl-3-(2-fluoro-5-(methylthio)phenyl)-1,6-naphthyridin-2(1H)-one