371-15-3

Basic information

• Product Name: 4-FLUOROTHIOANISOLE
• Synonyms: P-FLUORO(METHYLTHIO)BENZENE;4-FLUOROPHENYL METHYL SULFIDE;4-FLUOROTHIOANISOLE;1-FLUORO-4-(METHYLTHIO)BENZENE;4-Fluorophenyl methyl sulphide;4-Fluorothioanisole 97%;4-Fluorothioanisole97%;(4-fluorophenyl)(methyl)sulfane
• CAS NO: 371-15-3
• Molecular Formula: C₇H₇FS
• Molecular Weight: 142.19
• EINECS: 206-733-4
• Mol File: 371-15-3.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 184-185 °C
• Flash Point: 73 °C
• Appearance: clear colorless liquid
• Density: 1.167 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.987mmHg at 25°C
• Refractive Index: 1.55-1.552
• Sensitive: Stench
• BRN: 2041508
• CAS DataBase Reference: 4-FLUOROTHIOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROTHIOANISOLE(371-15-3)
• EPA Substance Registry System: 4-FLUOROTHIOANISOLE(371-15-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36/37/39
• RIDADR: 3334
• WGK Germany: 3
• HazardClass: IRRITANT, STENCH
• Hazardous Substances Data: 371-15-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

General Description

4-Fluorothioanisole is thioanisole derivative. Its conformations about the Csp2-S bond have been investigated by J method.

InChI:InChI=1/C7H7FS/c1-9-7-4-2-6(8)3-5-7/h2-5H,1H3

Upstream product

• 371-42-6 4-Fluorothiophenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 658-14-0 4-fluorophenyl methyl sulfoxide 
• 104-95-0 (4-bromophenyl)thioanisole 
• 455-15-2 1-(methylsufonyl)-4-fluorobenzene 
• 110-05-4 di-tert-butyl peroxide 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 624-92-0 Dimethyldisulphide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 616-38-6 carbonic acid dimethyl ester 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 455-15-2 1-(methylsufonyl)-4-fluorobenzene 
• 461-83-6 (4-fluoro-phenyl)-trichloromethyl sulfide 
• 126799-59-5 1-Methyl-4-phenyl-4-(4-(methylthio)phenoxy)piperidine 
• 57318-98-6 2-fluoro-5-(methylthio)benzoic acid 
• 108297-64-9 C₉H₁₁O₃S^(1-)*C₇H₉FNS⁽¹⁺⁾ 
• 658-14-0 4-fluorophenyl methyl sulfoxide 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 658-14-0 R-(-)-4-fluoro phenyl methyl sulfoxide 
• 175911-67-8 S-(+)-4-fluoro phenyl methyl sulfoxide 
• 252555-29-6 1-fluoro-2-methyl-4-methylsulfanyl-benzene 
• 2924-75-6 1-(Ethylthio)-4-fluorobenzene 
• 623-13-2 4-methylphenyl methylsulfide 
• 65398-69-8 1,2-Dimethyl-4-(methylthio)benzene 

Relevant articles and documents

Nickel-Catalyzed Direct Cross-Coupling of Aryl Sulfonium Salt with Aryl Bromide

The direct cross-couplings of aryl sulfonium salts with aryl halides could be achieved by using nickel as a reaction catalyst. The reactions proceeded efficiently via C-S bond activation in the presence of magnesium turnings and lithium chloride in THF at ambient temperature to afford the corresponding biaryls in moderate to good yields, potentially serving as an attractive alternative to conventional cross-coupling reactions employing preprepared organometallic reagents.

PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF

The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that are based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

Identification of MsrA homologues for the preparation of (R)-sulfoxides at high substrate concentrations

Here we report a methionine sulfoxide reductase A (MsrA) homologue with extremely high substrate tolerance and a wide substrate scope for the biocatalytic preparation of enantiopure sulfoxides. This MsrA homologue which was obtained from Pseudomonas alcaliphila (named paMsrA) showed good activity and enantioselectivity towards a series of aryl methyl/ethyl sulfoxides 1a-1k, with electron-withdrawing or electron-donating substituents at the aromatic ring. Chiral sulfoxides in the R configuration were prepared with approximately 50% of yield and up to 99% enantiomeric excess through the asymmetric reductive resolution of racemic sulfoxide catalyzed by the recombinant paMsrA protein. More importantly, kinetic resolution has been successfully accomplished with high enantioselectivity (E > 200) at initial substrate concentrations up to 320 mM (approximately 45 g L-1), which represents a great improvement in the aspect of the substrate concentration for the biocatalytic preparation of chiral sulfoxides.