[2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine

Base Information

Chemical Name:[2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine
CAS No.:467442-66-6
Molecular Formula:C₃₅H₃₇N₅O₂
Molecular Weight:559.711
Hs Code.:

Synonyms:[2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine

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Chemical Property of [2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine

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Technology Process of [2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine

There total 5 articles about [2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride

: 374633-82-6
4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenol

: 467442-66-6
[2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 2.5h; Heating;
DOI:10.1021/jm025545d

Reference yield:

: 61-54-1
tryptamine

: 467442-66-6
[2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / TFA / CH₂Cl₂ / 20 h

2: 60 percent / dimethylformamide / 16 h / 120 °C

3: 53 percent / BBr₃ / CH₂Cl₂ / 16 h

4: 66 percent / K₂CO₃ / dimethylformamide / 2.5 h / Heating

With boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm025545d

Reference yield:

: 55745-70-5
2,3-dihydro-benzofuran-5-carbaldehyde

: 467442-66-6
[2-(4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenoxy)-ethyl]-diethyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / TFA / CH₂Cl₂ / 20 h

2: 60 percent / dimethylformamide / 16 h / 120 °C

3: 53 percent / BBr₃ / CH₂Cl₂ / 16 h

4: 66 percent / K₂CO₃ / dimethylformamide / 2.5 h / Heating

With boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm025545d