Technology Process of (11aS)-2(R)-Hydroxy-8-methyl-9-(benzyloxy)-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine
There total 6 articles about (11aS)-2(R)-Hydroxy-8-methyl-9-(benzyloxy)-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / KOH / tetrahydrofuran; H2O; methanol / 12 h
2: 1.) oxalyl chloride, DMF, 2.) triethylamine / 1.) CH2Cl2, reflux, 40 min, 2.) THF, 0 deg C, 30 min
3: 1.) Na2S2SO4, 2.) aq. HCl / 1.) THF, H2O, room temp., 1.5 d, 2.) THF, H2O, room temp., 2 d
With
hydrogenchloride; potassium hydroxide; oxalyl dichloride; Na2S2SO4; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/ja00196a055
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / K2CO3 / dimethylformamide / 36 h / 65 °C
2: 80 percent / KOH / tetrahydrofuran; H2O; methanol / 12 h
3: 1.) oxalyl chloride, DMF, 2.) triethylamine / 1.) CH2Cl2, reflux, 40 min, 2.) THF, 0 deg C, 30 min
4: 1.) Na2S2SO4, 2.) aq. HCl / 1.) THF, H2O, room temp., 1.5 d, 2.) THF, H2O, room temp., 2 d
With
hydrogenchloride; potassium hydroxide; oxalyl dichloride; Na2S2SO4; potassium carbonate; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00196a055
- Guidance literature:
-
With
hydrogenchloride; Na2S2SO4;
Yield given. Multistep reaction;
1.) THF, H2O, room temp., 1.5 d, 2.) THF, H2O, room temp., 2 d;
DOI:10.1021/ja00196a055
