N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide

Base Information

• Chemical Name: N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide
• CAS No.: 1312937-83-9
• Molecular Formula: C₂₉H₃₀N₄O₂S
• Molecular Weight: 498.649
• Mol file: 1312937-83-9.mol

Synonyms:N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide

Chemical Property of N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide

There total 4 articles about N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H20N2S (1312938-00-3) + dansylamide (1431-39-6) → N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide (1312937-83-9)

Guidance literature:

With potassium hydrogencarbonate; In acetonitrile; for 72h; Reflux;

DOI:10.1016/j.tetlet.2011.04.031

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) → N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide (1312937-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 2 h / 20 °C / Inert atmosphere

2: acetonitrile / 18 h / 20 °C

3: potassium hydrogencarbonate / acetonitrile / 72 h / Reflux

With potassium hydrogencarbonate; In acetonitrile;

DOI:10.1016/j.tetlet.2011.04.031

Reference yield:

Benzyl isothiocyanate (622-78-6) → N'-benzyl-N-[(5-dimethylamino)naphthalene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboximidamide (1312937-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 2 h / 20 °C / Inert atmosphere

2: acetonitrile / 18 h / 20 °C

3: potassium hydrogencarbonate / acetonitrile / 72 h / Reflux

With potassium hydrogencarbonate; In acetonitrile;

DOI:10.1016/j.tetlet.2011.04.031

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

N-benzyl-3,4-dihydroisoquinoline-2(1H)-carbothioamide

C₁₈H₂₀N₂S

dansylamide