1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

Base Information

Chemical Name:1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one
CAS No.:1373243-61-8
Molecular Formula:C₃₁H₂₅NO₃
Molecular Weight:459.544
Hs Code.:

Synonyms:1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

Suppliers and Price of 1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

There total 9 articles about 1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1373243-60-7
1-benzhydryl-3-hydroxy-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

: 1373243-61-8
1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

Guidance literature:: 1-benzhydryl-3-hydroxy-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 10 ℃; for 3h;

With ammonium chloride; In water; at 0 ℃;

Reference yield:

: 6272-26-0
6-hydroxybenzofuran-3-one

: 1373243-61-8
1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 2.75 h / 0 - 50 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 0 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 3 h / 20 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C

5.2: 15 h / 0 - 20 °C

6.1: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 0 - 10 °C

6.2: 0 °C

With triethylsilane; aluminum (III) chloride; lithium aluminium tetrahydride; hydrogen; isopropylmagnesium chloride; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1373243-55-0
6-(benzyloxy)-3H-spiro[benzofuran-2,1'-cyclopropan]-3-one

: 1373243-61-8
1-benzhydryl-3-(6-hydroxy-3H-spiro[benzofuran-2,1'-cyclopropan]-5-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere

1.2: 0 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 3 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C

3.2: 15 h / 0 - 20 °C

4.1: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 0 - 10 °C

4.2: 0 °C

With triethylsilane; aluminum (III) chloride; lithium aluminium tetrahydride; hydrogen; isopropylmagnesium chloride; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;