Technology Process of rac-Cbz-2-amino tert-butyl-4,5-dihydroxy-2-methylpentanoate
There total 5 articles about rac-Cbz-2-amino tert-butyl-4,5-dihydroxy-2-methylpentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
AD-mix-β;
In
water; tert-butyl alcohol;
at 20 ℃;
for 12h;
DOI:10.1039/c1cc11573a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2: zinc(II) chloride; lithium diisopropyl amide / tetrahydrofuran / 16 h / -78 - 20 °C
3: boron trifluoride diethyl etherate / hexane; dichloromethane / 12 h
4: AD-mix-β / water; tert-butyl alcohol / 12 h / 20 °C
With
AD-mix-β; boron trifluoride diethyl etherate; caesium carbonate; zinc(II) chloride; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
2: Claisen type rearrangement / 4: Sharpless dihydroxylation;
DOI:10.1039/c1cc11573a
- Guidance literature:
-
Multi-step reaction with 3 steps
1: zinc(II) chloride; lithium diisopropyl amide / tetrahydrofuran / 16 h / -78 - 20 °C
2: boron trifluoride diethyl etherate / hexane; dichloromethane / 12 h
3: AD-mix-β / water; tert-butyl alcohol / 12 h / 20 °C
With
AD-mix-β; boron trifluoride diethyl etherate; zinc(II) chloride; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol;
1: Claisen type rearrangement / 3: Sharpless dihydroxylation;
DOI:10.1039/c1cc11573a
