5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

Base Information

Chemical Name:5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol
CAS No.:853734-14-2
Molecular Formula:C₃₉H₅₆O₁₃Si
Molecular Weight:760.951
Hs Code.:

Synonyms:5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

Suppliers and Price of 5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

There total 6 articles about 5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 853734-13-1
5-O-acetyl-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

: 339276-10-7
2,3,4-tri-O-acetyl-L-rhamnopyranosyl (N-phenyl)-2,2,2-trifluoroacetimidate

: 853734-14-2
5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ol050324y

Reference yield:

: 3,6-di-O-benzyl-L-arabinopyranose

: 853734-14-2
5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / NaBH₄ / ethanol / 5 h / 20 °C

2: 77 percent / TsOH; 3 Angstroem molecular sieves / 4 h / 20 °C

3: 77 percent / pyridine / 20 °C

4: aq. AcOH / 2 h / 40 °C

5: 139 mg / imidazole / dimethylformamide / 2 h / 0 °C

6: 88 percent / TMSOTf; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; trimethylsilyl trifluoromethanesulfonate; 3 A molecular sieve; 4 A molecular sieve; toluene-4-sulfonic acid; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol050324y

Reference yield:

: 853734-11-9
3,4-di-O-benzyl-1,2-O-isopropylidene-L-arabitol

: 853734-14-2
5-O-acetyl-2-[O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)]-3,4-di-O-benzyl-1-O-tert-butyldimethylsilyl-L-arabitol

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / pyridine / 20 °C

2: aq. AcOH / 2 h / 40 °C

3: 139 mg / imidazole / dimethylformamide / 2 h / 0 °C

4: 88 percent / TMSOTf; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol050324y