N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide

Base Information

• Chemical Name: N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide
• CAS No.: 206664-10-0
• Molecular Formula: C₁₅H₁₀FNO₄
• Molecular Weight: 287.247
• Mol file: 206664-10-0.mol

Synonyms:N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide

Chemical Property of N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide

There total 3 articles about N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(4-fluorophenyl)isoquinoline-1,3(2H,4H)-dione (206663-94-7) → 2-(4-fluorophenyl)-1,3,4(2H)-isoquinolinetrione + N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide (206664-10-0)

Guidance literature:

With oxygen; In pyridine; benzene; for 10h; Ambient temperature; Irradiation; sensitizer: tetraphenylporphin;

DOI:10.1016/S0040-4039(98)00344-X

Reference yield:

homophthalic anhydride (703-59-3) → N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide (206664-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / acetic acid / Heating

2: 22 percent / O₂; TPP / benzene; pyridine / 10 h / Irradiation

With oxygen; thiamine diphosphate; In pyridine; acetic acid; benzene; 1: Substitution / 2: Oxidation;

DOI:10.1016/S0040-4020(99)00502-5

Reference yield:

4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-3-hydroxyisobenzofuran-1-one-3-carbamide (206664-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / acetic acid / Heating

2: 22 percent / O₂; TPP / benzene; pyridine / 10 h / Irradiation

With oxygen; thiamine diphosphate; In pyridine; acetic acid; benzene; 1: Substitution / 2: Oxidation;

DOI:10.1016/S0040-4020(99)00502-5

upstream raw materials:

2-(4-fluorophenyl)isoquinoline-1,3(2H,4H)-dione

homophthalic anhydride

4-fluoroaniline