(R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol

Base Information

Chemical Name:(R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol
CAS No.:1394849-53-6
Molecular Formula:C₁₇H₃₀O₃Si
Molecular Weight:310.509
Hs Code.:

Synonyms:(R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol

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Chemical Property of (R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol

Chemical Property:

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Technology Process of (R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol

There total 5 articles about (R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

: 1394849-52-5
(S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

: 1394849-53-6
(R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol

Guidance literature:: With potassium carbonate; In methanol; at 25 ℃; for 1h;
DOI:10.1021/op3001383

Reference yield:

: 117087-17-9
5-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxane

: 1394849-53-6
(R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / water; isopropyl alcohol / 3 h / 25 °C / Large scale

2: Lipase AS Amano from (Aspergillus niger) / dimethyl sulfoxide / 20 h / 37 °C / pH 7.5 / Enzymatic reaction

3: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / -20 °C

4: potassium carbonate / methanol / 1 h / 25 °C

With 2,6-dimethylpyridine; hydrogenchloride; Lipase AS Amano from (Aspergillus niger); potassium carbonate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/op3001383

Reference yield:

: 117087-18-0
2-((benzyloxy)methyl)propane-1,3-diol

: 1394849-53-6
(R)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: Lipase AS Amano from (Aspergillus niger) / dimethyl sulfoxide / 20 h / 37 °C / pH 7.5 / Enzymatic reaction

2: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / -20 °C

3: potassium carbonate / methanol / 1 h / 25 °C

With 2,6-dimethylpyridine; Lipase AS Amano from (Aspergillus niger); potassium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1021/op3001383