methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

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Chemical Name:methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate
CAS No.:1352392-98-3
Molecular Formula:C₃₄H₃₇N₇O₃
Molecular Weight:591.713
Hs Code.:

methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

Synonyms:methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

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Chemical Property of methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

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Technology Process of methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

There total 6 articles about methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-tert-butyl 2-(6-((4-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)ethynyl)-1H-benzo[d]imidazol-2-yl)-4-methyl-2,5-dihydro-1H-pyrrole-1-carboxylate

: 1352392-98-3
methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 102195-80-2
(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

: 1352392-98-3
methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: 3 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 95 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

3.2: pH 3

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 20 °C

4.2: 1 h

5.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 110 °C / sealed tube

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With lithium hydroxide monohydrate; water; sodium hexamethyldisilazane; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Sonogashira Coupling;

Reference yield:

: 1228215-10-8
(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1352392-98-3
methyl (S)-3-methyl-1-((S)-2-(5-(4-((2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 20 °C

2.2: 1 h

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 110 °C / sealed tube

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With lithium hydroxide monohydrate; water; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Sonogashira Coupling;