tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate
• CAS No.: 896127-78-9
• Molecular Formula: C₂₅H₃₁ClFN₃O₄
• Molecular Weight: 491.99

Synonyms:tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amine + 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid (157688-46-5) → tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate (896127-78-9)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate (896127-78-9) → C20H23ClFN3O2

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 1h;

Reference yield:

tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate (896127-78-9) → C20H23ClFN3O2*ClH

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water;

DOI:10.1016/j.bmcl.2009.05.067

upstream raw materials:

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

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