5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide

Base Information

Chemical Name:5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide
CAS No.:327037-25-2
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:

Synonyms:5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide

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Chemical Property of 5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide

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Technology Process of 5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide

There total 3 articles about 5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1743-01-7,49812-93-3
JGC 127 hydrochloride

: 135321-95-8
2-hydroxy-5-<(tert-butoxycarbonyl)amino>benzoic acid

: 327037-25-2
5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide

Guidance literature:: 2-hydroxy-5-<(tert-butoxycarbonyl)amino>benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

JGC 127 hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Further stages.;
DOI:10.1021/jm000387g

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 327037-25-2
5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / Et₃N / dioxane; H₂O / 24 h / 20 °C

2.1: EDCI; HOBt; Et₃N / dimethylformamide / 24 h / 20 °C

2.2: 59 percent / dimethylformamide / 48 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000387g

Reference yield:

: 89-57-6
5-Aminosalicylic Acid

: 327037-25-2
5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / Et₃N / dioxane; H₂O / 24 h / 20 °C

2.1: EDCI; HOBt; Et₃N / dimethylformamide / 24 h / 20 °C

2.2: 59 percent / dimethylformamide / 48 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000387g