[(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester

Base Information

Chemical Name:[(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester
CAS No.:779335-39-6
Molecular Formula:C₂₂H₃₇N₂O₅P
Molecular Weight:440.52
Hs Code.:

Synonyms:[(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester

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Chemical Property of [(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester

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Technology Process of [(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester

There total 4 articles about [(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

: 27687-42-9
[(methyl-phenyl-carbamoyl)-methyl]-phosphonic acid diethyl ester

: 779335-39-6
[(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester

Guidance literature:: [(methyl-phenyl-carbamoyl)-methyl]-phosphonic acid diethyl ester; With lithium diisopropyl amide; In 1,2-dimethoxyethane; hexane; at -60 ℃; for 0.5h;

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; With copper dichloride; In 1,2-dimethoxyethane; hexane; at -60 - 0 ℃;
DOI:10.1021/ol048759t

Reference yield:

: 3095-95-2
diethylphosphonoacetic acid

: 779335-39-6
[(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 4 h / 20 °C

2.1: 60 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

3.1: LDA / 1,2-dimethoxy-ethane; hexane / 0.5 h / -60 °C

3.2: 75 percent / CuCl₂ / 1,2-dimethoxy-ethane; hexane / -60 - 0 °C

With thionyl chloride; triethylamine; lithium diisopropyl amide; In 1,2-dimethoxyethane; hexane; dichloromethane;
DOI:10.1021/ol048759t

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 779335-39-6
[(methyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaOH / 3 h / 20 °C

2.1: thionyl chloride / 4 h / 20 °C

3.1: 60 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

4.1: LDA / 1,2-dimethoxy-ethane; hexane / 0.5 h / -60 °C

4.2: 75 percent / CuCl₂ / 1,2-dimethoxy-ethane; hexane / -60 - 0 °C

With sodium hydroxide; thionyl chloride; triethylamine; lithium diisopropyl amide; In 1,2-dimethoxyethane; hexane; dichloromethane;
DOI:10.1021/ol048759t