N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester

Base Information

• Chemical Name: N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester
• CAS No.: 88767-05-9
• Molecular Formula: C₁₆H₂₀N₄O₇
• Molecular Weight: 380.357

Synonyms:N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester

Chemical Property of N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester

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Technology Process of N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester

There total 1 articles about N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-(1-cyclohexyl-4-nitro-2-oxo-2,5-dihydro-pyrrol-3-yl)-glycine (52555-24-5) → N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester (88767-05-9) + 1,3-Dicyclohexylurea (2387-23-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo00180a036

Reference yield: 71.0%

L-Phe-Leu (3303-55-7) + N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester (88767-05-9) → N-(c-NOPY)-glycyl-L-phenylalanyl-L-leucine (88767-09-3)

Guidance literature:

With 1-methyl-piperazine; potassium carbonate; In water; N,N-dimethyl-formamide; acetonitrile; for 2h; Ambient temperature;

DOI:10.1021/jo00180a036

Reference yield: 70.0%

N-(1-Cyclohexyl-4-nitro-2-oxo-3-pyrroline-3-yl)-glycine-N-hydroxy-succinimide ester (88767-05-9) + L-Phenylalanyl-L-leucine ethylester hydrochloride (88767-10-6) → N-(c-NOPY)-glycyl-L-phenylalanyl-L-leucine ethyl ester (88767-07-1)

Guidance literature:

With 4-methyl-morpholine; N,N-dimethylethylenediamine; In tetrahydrofuran; at 0 - 25 ℃;

DOI:10.1021/jo00180a036

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-(1-cyclohexyl-4-nitro-2-oxo-2,5-dihydro-pyrrol-3-yl)-glycine

Downstream raw materials:

N-(c-NOPY)-glycyl-L-phenylalanyl-L-leucine

N-(c-NOPY)-glycyl-L-phenylalanyl-L-leucine ethyl ester

3-amino-1-cyclohexyl-4-nitro-1,5-dihydro-pyrrol-2-one

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