(2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate

Base Information

• Chemical Name: (2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate
• CAS No.: 1036969-66-0
• Molecular Formula: C₂₅H₂₅NO₃
• Molecular Weight: 387.478
• Mol file: 1036969-66-0.mol

Synonyms:(2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate

Chemical Property of (2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate

There total 4 articles about (2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + 4-methoxybenzylidenediphenylmethylamine (50289-28-6,40462-63-3) → (2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate (1036969-66-0) + (2R,3R)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate

Guidance literature:

With (R)-vanol catalyst; In toluene; at 25 ℃; for 24h; optical yield given as %ee;

DOI:10.1002/chem.200701558

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + 4-methoxybenzylidenediphenylmethylamine (50289-28-6,40462-63-3) → C25H25NO3 + (2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate (1036969-66-0) + C25H25NO3

Guidance literature:

With (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; In toluene; at 25 ℃; for 24h; enantioselective reaction;

DOI:10.1039/c4cy00742e

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + 4-methoxybenzylidenediphenylmethylamine (50289-28-6,40462-63-3) → C25H25NO3 + (2S,3S)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate (1036969-66-0) + C25H25NO3 + (2R,3R)-ethyl 1-benzhydryl-3-(4-methoxyphenyl)aziridine-2-carboxylate

Guidance literature:

With (S)-iso-VAPOL; In toluene; at 25 ℃; for 24h; enantioselective reaction;

DOI:10.1039/c4cy00742e

upstream raw materials:

diazoacetic acid ethyl ester

4-methoxybenzylidenediphenylmethylamine