(E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide

Base Information

Chemical Name:(E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide
CAS No.:1333393-91-1
Molecular Formula:C₂₆H₂₁ClN₄O₃S₂
Molecular Weight:537.063
Hs Code.:

Synonyms:(E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide

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Chemical Property of (E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide

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Technology Process of (E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide

There total 8 articles about (E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1333393-84-2
3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)aniline

: 216955-76-9
(E)-2-(3’ chlorophenyl)ethene-1-sulfonyl chloride

: 1333393-91-1
(E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2011.07.023

Reference yield:

: 17890-56-1
benzothiophene-2-methanol

: 1333393-91-1
(E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; triphenylphosphine / tetrachloromethane; N,N-dimethyl-formamide / 4 h / 90 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol; water / 24 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

4: sodium carbonate / tetrahydrofuran; water / 3 h / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.023

Reference yield:

: 1333393-76-2
2-(azidomethyl)benzo[b]thiophene

: 1333393-91-1
(E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol; water / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: sodium carbonate / tetrahydrofuran; water / 3 h / 20 °C

With copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.07.023