tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate

Base Information

Chemical Name:tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate
CAS No.:1333394-23-2
Molecular Formula:C₂₃H₂₄N₄O₃S
Molecular Weight:436.535
Hs Code.:

Synonyms:tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate

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Chemical Property of tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate

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Technology Process of tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate

There total 5 articles about tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1333393-76-2
2-(azidomethyl)benzo[b]thiophene

: 1333393-77-3
tert-butyl 3-(prop-2-ynyloxy)phenylcarbamate

: 1333394-23-2
tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; water; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2011.07.023

Reference yield:

: 17890-56-1
benzothiophene-2-methanol

: 1333394-23-2
tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; triphenylphosphine / tetrachloromethane; N,N-dimethyl-formamide / 4 h / 90 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol; water / 24 h / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triphenylphosphine; In tetrachloromethane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.023

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1333394-23-2
tert-butyl 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 25 h / 61 °C

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 45 h / 68 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol; water / 24 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; sodium iodide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.023