5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-pyridinyl)-,ethylester(9CI)

Base Information

Chemical Name:5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-pyridinyl)-,ethylester(9CI)
CAS No.:367908-21-2
Molecular Formula:C₁₃H₁₅N₃O₃
Molecular Weight:261.28
Hs Code.:
Mol file:367908-21-2.mol

Synonyms:5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-pyridinyl)-,ethylester(9CI)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-pyridinyl)-,ethylester(9CI)

Chemical Property:

PSA：83.81000
LogP:1.24140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-pyridinyl)-,ethylester(9CI)

There total 3 articles about 5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-pyridinyl)-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 500-22-1
3-pyridinecarboxaldehyde

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 367908-21-2
ethyl 6-methyl-2-oxo-4-(pyridin-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With 2,2,2-trifluoroethanol; at 80 ℃;
DOI:10.1080/00397911.2010.525335

Reference yield: 75.0%

: 100-55-0
3-hydroxymethylpyridin

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 367908-21-2
ethyl 6-methyl-2-oxo-4-(pyridin-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: 3-hydroxymethylpyridin; With T₃P; dimethyl sulfoxide; In ethyl acetate; at 20 ℃; Inert atmosphere; Green chemistry;

ethyl acetoacetate; urea; In ethyl acetate; at 60 - 70 ℃; Solvent; Temperature; Inert atmosphere; Green chemistry;
DOI:10.1246/cl.130732