Technology Process of methyl 4-[(3,4-dichlorophenyl)acetyl]-3-formyl-1-piperazinecarboxylate
There total 7 articles about methyl 4-[(3,4-dichlorophenyl)acetyl]-3-formyl-1-piperazinecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 67 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Ambient temperature
2: 91 percent / H2, aq. HCl / 10percent Pd/C / tetrahydrofuran / 2.5 h
3: 23 percent / Et3N / acetonitrile / 0.17 h / 5 °C
4: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH
5: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) Et3N / 1.) dichloromethane, -65 deg C, 3 h, 2.) dichloromethane, from -65 deg C to -20 deg C
With
hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 88 percent / H2 / 5percent Pd/C / ethanol / 24 h / Ambient temperature
2: 67 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Ambient temperature
3: 91 percent / H2, aq. HCl / 10percent Pd/C / tetrahydrofuran / 2.5 h
4: 23 percent / Et3N / acetonitrile / 0.17 h / 5 °C
5: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH
6: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) Et3N / 1.) dichloromethane, -65 deg C, 3 h, 2.) dichloromethane, from -65 deg C to -20 deg C
With
hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm00067a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / H2, aq. HCl / 10percent Pd/C / tetrahydrofuran / 2.5 h
2: 23 percent / Et3N / acetonitrile / 0.17 h / 5 °C
3: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH
4: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) Et3N / 1.) dichloromethane, -65 deg C, 3 h, 2.) dichloromethane, from -65 deg C to -20 deg C
With
hydrogenchloride; lithium hydroxide; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004
