N²-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Base Information

• Chemical Name: N²-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide
• CAS No.: 1352086-71-5
• Molecular Formula: C₁₉H₂₃ClN₄O₂
• Molecular Weight: 374.87

Synonyms:N²-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Chemical Property of N²-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Chemical Property:

Purity/Quality:

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Technology Process of N²-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

There total 14 articles about N²-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyl-6-chloro-8-cyano-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide (1352087-23-0) → N2-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352086-71-5)

Guidance literature:

With water; dihydrogen peroxide; sodium hydroxide; In methanol; dimethyl sulfoxide; at 65 ℃; for 1.25h;

Reference yield:

8-carbamoyl-6-chloro-7-phenyl-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride (1352087-43-4) + Tert-butyl isocyanate (1609-86-5) → N2-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352086-71-5)

Guidance literature:

With triethylamine; In Difluoromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

cinnamic nitrile (1885-38-7) → N2-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352086-71-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 20 - 25 °C

2.1: N-chloro-succinimide / tetrahydrofuran / 48 h / Reflux

3.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

3.2: 4 h / Reflux

4.1: hydrogenchloride / ethanol; water / 1 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 4 h / Heating

6.1: dichloromethane / 4 h / 20 °C

7.1: sodium hydroxide; water; dihydrogen peroxide / dimethyl sulfoxide; methanol / 1.25 h / 65 °C

With hydrogenchloride; N-chloro-succinimide; potassium tert-butylate; water; dihydrogen peroxide; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

cinnamic nitrile

8-carbamoyl-6-chloro-7-phenyl-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Tert-butyl isocyanate

4-phenyl-1H-pyrrole-3-carbonitrile

Downstream raw materials:

N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

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