Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester

Base Information

Chemical Name:Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester
CAS No.:76915-80-5
Molecular Formula:C₁₆H₁₉NO₅S₂
Molecular Weight:369.463
Hs Code.:

Synonyms:Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester

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Chemical Property of Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester

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Technology Process of Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester

There total 12 articles about Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 583-61-9
2,3-Lutidine

: 76915-80-5
Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: azobis(isobutyronitrile), NBS / CCl₄ / 1.5 h / Heating; Irradiation

2: 58 percent / ethanol / 1 h / Heating

3: aq. NaIO₄ / methanol / 6 h / Ambient temperature

4: KMnO₄ / methanol; H₂O / 0.5 h / Ambient temperature

5: 84 percent / NBS, azobis(isobutyronitrile) / CCl₄ / 2 h / Heating; Irradiation

6: ethanol / 1 h / Ambient temperature

7: 80 percent / LDA, TMEDA / tetrahydrofuran / 1 h / -78 °C

8: 1.) OsO₄, NaIO₄, 2.) 1,5-diazabicyclo<5.4.2>undecene (DBU) / 1.) THF/H₂O/ether, RT, 1 h, 2.) THF, overnight

9: 20 percent / H₂ / 5percent Pd/C / methanol / 1 h / Ambient temperature

10: triethylamine / CH₂Cl₂ / 1 h / 0 °C

With potassium permanganate; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water;
DOI:10.1021/jo00323a016

Reference yield:

: 56826-61-0
(2-methylpyridin-3-yl)methanol

: 76915-80-5
Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: PBr₃ / diethyl ether / 1 h

2: 58 percent / ethanol / 1 h / Heating

3: aq. NaIO₄ / methanol / 6 h / Ambient temperature

4: KMnO₄ / methanol; H₂O / 0.5 h / Ambient temperature

5: 84 percent / NBS, azobis(isobutyronitrile) / CCl₄ / 2 h / Heating; Irradiation

6: ethanol / 1 h / Ambient temperature

7: 80 percent / LDA, TMEDA / tetrahydrofuran / 1 h / -78 °C

8: 1.) OsO₄, NaIO₄, 2.) 1,5-diazabicyclo<5.4.2>undecene (DBU) / 1.) THF/H₂O/ether, RT, 1 h, 2.) THF, overnight

9: 20 percent / H₂ / 5percent Pd/C / methanol / 1 h / Ambient temperature

10: triethylamine / CH₂Cl₂ / 1 h / 0 °C

With potassium permanganate; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; hydrogen; phosphorus tribromide; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00323a016

Reference yield:

: 1721-26-2
ethyl 2-methyl nicotinate

: 76915-80-5
Methanesulfonic acid 3-(2-benzenesulfonylmethyl-pyridin-3-yl)-propyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: LiAlH₄ / diethyl ether / 1 h / Ambient temperature

2: PBr₃ / diethyl ether / 1 h

3: 58 percent / ethanol / 1 h / Heating

4: aq. NaIO₄ / methanol / 6 h / Ambient temperature

5: KMnO₄ / methanol; H₂O / 0.5 h / Ambient temperature

6: 84 percent / NBS, azobis(isobutyronitrile) / CCl₄ / 2 h / Heating; Irradiation

7: ethanol / 1 h / Ambient temperature

8: 80 percent / LDA, TMEDA / tetrahydrofuran / 1 h / -78 °C

9: 1.) OsO₄, NaIO₄, 2.) 1,5-diazabicyclo<5.4.2>undecene (DBU) / 1.) THF/H₂O/ether, RT, 1 h, 2.) THF, overnight

10: 20 percent / H₂ / 5percent Pd/C / methanol / 1 h / Ambient temperature

11: triethylamine / CH₂Cl₂ / 1 h / 0 °C

With potassium permanganate; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; hydrogen; phosphorus tribromide; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00323a016