(2R,3S,5S)-2-((S)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester

Base Information

Chemical Name:(2R,3S,5S)-2-((S)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester
CAS No.:85880-01-9
Molecular Formula:C₂₃H₃₄ClNO₇S
Molecular Weight:504.044
Hs Code.:

Synonyms:(2R,3S,5S)-2-((S)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester

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Chemical Property of (2R,3S,5S)-2-((S)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester

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Technology Process of (2R,3S,5S)-2-((S)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester

There total 15 articles about (2R,3S,5S)-2-((S)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73252-36-5
(S)-3-(methoxymethoxy)-1-butanol

: 85880-01-9
(2R,3S,5S)-2-((S)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / dimethylsulfoxide / -60 °C

2: 85 percent / Wadsworth-Horner-Emmons reaction

3: 2.) 1,2-epoxybutane / 1.) CH₂Cl₂, 2.) acetonitrile, 80 deg C

With ethyloxirane; oxalyl dichloride; In dimethyl sulfoxide;
DOI:10.1021/ja00522a085

Reference yield:

: 62574-13-4
L-cystine tert-butyl ester

: 73252-39-8,85880-01-9
(2R,3S)-2-((R)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 15 h / 0 - 25 °C

2: sodium borohydride / ethanol

3: N-chlorosuccinimide / CH₂Cl₂ / 25 °C

4: 2.) 1,2-epoxybutane / 1.) CH₂Cl₂, 2.) acetonitrile, 80 deg C

With ethyloxirane; pyridine; sodium tetrahydroborate; N-chloro-succinimide; In ethanol; dichloromethane;
DOI:10.1021/ja00522a085

Reference yield:

: 98-88-4
benzoyl chloride

: 73252-39-8,85880-01-9
(2R,3S)-2-((R)-2-Benzoylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-chloro-5-methoxymethoxy-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 15 h / 0 - 25 °C

2: sodium borohydride / ethanol

3: N-chlorosuccinimide / CH₂Cl₂ / 25 °C

4: 2.) 1,2-epoxybutane / 1.) CH₂Cl₂, 2.) acetonitrile, 80 deg C

With ethyloxirane; pyridine; sodium tetrahydroborate; N-chloro-succinimide; In ethanol; dichloromethane;
DOI:10.1021/ja00522a085