(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester

Base Information

Chemical Name:(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester
CAS No.:196950-21-7
Molecular Formula:C₂₃H₃₃N₃O₈
Molecular Weight:479.53
Hs Code.:

Synonyms:(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester

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Chemical Property of (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester

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Technology Process of (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester

There total 5 articles about (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 196950-18-2
γ-Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) diester

: 196950-21-7
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid; for 21h;
DOI:10.1039/a702410j

Reference yield:

: 118700-84-8
(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid

: 196950-21-7
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1039/a702410j

Reference yield:

: 110473-10-4
N-Boc-D-Glu α-methyl ester

: 196950-21-7
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamate) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / HCl / ethyl acetate / 1 h / 0 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;
DOI:10.1039/a702410j