di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

Base Information

Chemical Name:di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate
CAS No.:221077-02-7
Molecular Formula:C₃₆H₅₀N₂O₉
Molecular Weight:654.801
Hs Code.:

Synonyms:di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

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Chemical Property of di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

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Technology Process of di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

There total 1 articles about di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 35207-75-1
di-tert-butyl diazomalonate

: 221077-01-6
benzyl 4-{[(1S)-1-(4-hydroxybenzyl)-2-oxo-2-(pentylamino)ethyl]amino}-4-oxobutanoate

: 221077-02-7
di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

Guidance literature:: With dirhodium tetraacetate; In benzene; at 80 ℃;
DOI:10.1021/jm010393s

Reference yield:

: 221077-02-7
di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

: 221075-10-1
(S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm010393s

Reference yield:

: 221077-02-7
di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

: (S)-[4-[2-[(3-carboxy-1-oxopropyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 1.5 h / 760.05 Torr

With hydrogen; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm010393s