(S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

Base Information

Chemical Name:(S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid
CAS No.:221075-10-1
Molecular Formula:C₂₈H₃₄N₂O₉
Molecular Weight:542.586
Hs Code.:

Synonyms:(S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

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Chemical Property of (S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

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Technology Process of (S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

There total 3 articles about (S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221077-02-7
di-tert-butyl 2-{4-[(2S)-2-{[4-(benzyloxy)-4-oxobutanoyl]amino}-3-oxo-3-(pentylamino)propyl]phenoxy}malonate

: 221075-10-1
(S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm010393s

Reference yield:

: 221077-01-6
benzyl 4-{[(1S)-1-(4-hydroxybenzyl)-2-oxo-2-(pentylamino)ethyl]amino}-4-oxobutanoate

: 221075-10-1
(S)-[4-[2-[[1,4-dioxo-4-(phenylmethoxy)butyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / Rh₂(OAc)4 / benzene / 80 °C

2: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With dirhodium tetraacetate; trifluoroacetic acid; In dichloromethane; benzene;
DOI:10.1021/jm010393s