Gly-Phe-O-methyl ester hydrochloride

Base Information

• Chemical Name: Gly-Phe-O-methyl ester hydrochloride
• CAS No.: 33194-22-8
• Molecular Formula: C₁₂H₁₆N₂O₃*ClH
• Molecular Weight: 272.732
• Mol file: 33194-22-8.mol

Synonyms:Gly-Phe-O-methyl ester hydrochloride

Chemical Property of Gly-Phe-O-methyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Gly-Phe-O-methyl ester hydrochloride

There total 2 articles about Gly-Phe-O-methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(2-(tert-butoxycarbonylamino)acetamido)-3-phenylpropanoate (106624-70-8) → Gly-Phe-O-methyl ester hydrochloride (33194-22-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 0.5h;

DOI:10.1016/j.ejps.2004.04.013

Reference yield:

methyl 2-amino-3-phenylpropanoate hydrochloride (5619-07-8) → Gly-Phe-O-methyl ester hydrochloride (33194-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodimide hydrochloride / dimethylformamide / 0.5 h / 20 °C

1.2: N,N-diisopropylethylamine / 20 °C

2.1: HCl / ethyl acetate / 0.5 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.ejps.2004.04.013

Reference yield: 89.0%

Methyl 2,3-dibromopropionate (1729-67-5) + Gly-Phe-O-methyl ester hydrochloride (33194-22-8) → 1-[(1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-methyl]-aziridine-2-carboxylic acid methyl ester (84899-37-6)

Guidance literature:

With triethylamine; at 50 ℃; for 14h;

DOI:10.1007/BF00506610

upstream raw materials:

methyl 2-(2-(tert-butoxycarbonylamino)acetamido)-3-phenylpropanoate

methyl 2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

1-[(1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-methyl]-aziridine-2-carboxylic acid methyl ester