(S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester

Base Information

Chemical Name:(S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester
CAS No.:725270-45-1
Molecular Formula:C₂₂H₃₁NO₃Si
Molecular Weight:385.579
Hs Code.:

Synonyms:(S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester

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Technology Process of (S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester

There total 2 articles about (S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 725270-29-1
(S)-(+)-benzyl 2-cyano-2-phenyl-2-tert-butyldimethylsiloxyacetate

: 725270-45-1
(S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; cobalt(II) chloride; In methanol; at 0 - 25 ℃;
DOI:10.1021/jo049164e

Reference yield:

: 132868-67-8
(tert-butyldimethylsilyl)(phenyl)methanone

: 725270-45-1
(S)-(+)-3-amino-2-phenyl-2-tert-butyldimethylsilyloxypropionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (1R,2R)-((E)-N=CH-[2-OH-3-(t-Bu)-5-Cl-phenyl])2-cyclohexane; Al(O-i-Pr)3 / toluene / 72 h / 45 °C

2: CoCl₂*6H₂O; NaBH₄ / methanol / 0 - 20 °C

With sodium tetrahydroborate; (1R,2R)-((E)-N=CH-[2-OH-3-(t-Bu)-5-Cl-phenyl])2-cyclohexane; aluminum isopropoxide; cobalt(II) chloride; In methanol; toluene;
DOI:10.1002/anie.200353354