Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 365441-87-8
• Molecular Formula: C9H19 N O2
• Molecular Weight: 173.255
• Mol file: 365441-87-8.mol

Synonyms:Carbamicacid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Boiling Point: 124 °C (10 mmHg)
• PSA: 38.33000
• LogP: 2.55800

Purity/Quality:

99% ^*data from raw suppliers

tert-butylN-(2-methylpropyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

There total 8 articles about Carbamic acid, (2-methylpropyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tert-butyldicarbonate (34619-03-9) + isobutylamine (78-81-9) → 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylpropanoic acid (365441-87-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 15.1667h;

DOI:10.1002/anie.201310904

Reference yield: 82.0%

[2-methyl-1-(toluene-4-sulfonyl)-propyl]-carbamic acid tert-butyl ester (271600-32-9) → 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylpropanoic acid (365441-87-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(01)00895-4

Reference yield: 78.0%

t-Boc-L-valine (13734-41-3) → 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylpropanoic acid (365441-87-8)

Guidance literature:

With terephthalonitrile; 2,3,3,4,4,5-hexamethyl-2-hexanethiol; phenanthrene; In water; acetonitrile; at 20 ℃; for 6h; Irradiation;

DOI:10.1039/b714526h

upstream raw materials:

[2-methyl-1-(toluene-4-sulfonyl)-propyl]-carbamic acid tert-butyl ester

3-methylbutyric acid

di-tert-butyl dicarbonate

tert-butyl methyl iminodicarboxylate

Downstream raw materials:

tert-butyl isobutyl(4-(trifluoromethyl)phenethyl-1,2,2-D₃)carbamate

isobutyl isocyanate

N-isobutyl-3-phenylpropionamide

N-isobutyl-benzamide