benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

Base Information

Chemical Name:benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate
CAS No.:1350918-31-8
Molecular Formula:C₃₈H₄₉FN₆O₄Si
Molecular Weight:700.929
Hs Code.:

benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

Synonyms:benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

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Chemical Property of benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

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Technology Process of benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

There total 9 articles about benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1350918-27-2
4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylic acid

: 1350918-30-7
benzyl (2-(1-(2-amino-6-fluorophenyl)piperidin-4-yl)propan-2-yl)carbamate

: 1350918-31-8
benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1350918-31-8
benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

4: sodium hydroxide; methanol / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With methanol; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 954125-17-8
ethyl 4-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazole-2-carboxylate

: 1350918-31-8
benzyl (2-(1-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)piperidin-4-yl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

2: sodium hydroxide; methanol / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With methanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide;