dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester

Base Information

• Chemical Name: dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester
• CAS No.: 663180-16-3
• Molecular Formula: C₁₈H₂₀N₂O₆
• Molecular Weight: 360.367
• Mol file: 663180-16-3.mol

Synonyms:dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester

Chemical Property of dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester

There total 7 articles about dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

dimethyl-carbamic acid 4-[1-(tert-butyl-dimethyl-silanyloxy)-3-(4-nitro-phenoxy)-propyl]-phenyl ester (663180-14-1) → dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester (663180-16-3)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 6h;

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester (663180-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran; toluene / 1 h / 20 °C

2: 78 percent / HCl / methanol; H₂O / 6 h / 20 °C

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; toluene; 1: Mitsunobu reaction;

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → dimethyl-carbamic acid 4-[1-hydroxy-3-(4-nitro-phenoxy)-propyl]-phenyl ester (663180-16-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 99 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

2.1: iPr₂NLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 92 percent / hexane; tetrahydrofuran / 1 h / -78 °C

3.1: 90 percent / imidazole / dimethylformamide / 12 h / 20 °C

4.1: 67 percent / LiBH₄ / tetrahydrofuran / 2 h / 60 °C

5.1: 90 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran; toluene / 1 h / 20 °C

6.1: 78 percent / HCl / methanol; H₂O / 6 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium borohydride; potassium carbonate; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; toluene; 5.1: Mitsunobu reaction;

upstream raw materials:

dimethyl-carbamic acid 4-[1-(tert-butyl-dimethyl-silanyloxy)-3-(4-nitro-phenoxy)-propyl]-phenyl ester

4-nitro-phenol

4-hydroxy-benzaldehyde

4-formylphenyl N,N-dimethylcarbamate

Downstream raw materials:

dimethylcarbamic acid 4-[1-bromo-3-(4-nitrophenoxy)propyl]phenyl ester