(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester

Base Information

Chemical Name:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester
CAS No.:72522-81-7
Molecular Formula:C₁₈H₂₅F₃O₃
Molecular Weight:346.39
Hs Code.:

Synonyms:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester

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Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester

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Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester

There total 10 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60182-96-9
2-amino-3-methylhexanoic acid

: 72522-81-7
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / acetic acid / 0.08 h / Heating

2: 12.2 g / NaOH, Aspergillus acylase, CoCl₂ / H₂O / 120 h / 37 °C / pH=6.5

3: 63 percent / 2N HCl / 2 h / Heating

4: 82 percent / NaNO₂, 1.5N H₂SO₄ / H₂O / 1.) 0-5 deg C, 1 h; 2.) 0-30 deg C, 2 h

5: 56 percent / LAH / diethyl ether / 1.) 0-5 deg C, 1 h; 2.) RT, 1 h

6: 1.) 30percent HBr; 2.) NaOMe / 1.) H₂O, a.) 0-5 deg C, 10 min; b.) RT, 1 h; 2.) MeOH, RT, 1 h

7: 1.) Li, CuI / 1.) ether, -30 to -20 deg C; 2.) ether, a.) -28 to -18 deg C, b.) -40 to 0 deg C within 4 h

With hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; Aspergillus acylase; sulfuric acid; hydrogen bromide; sodium methylate; lithium; sodium nitrite; In diethyl ether; water; acetic acid;
DOI:10.1016/0040-4020(80)80113-X

Reference yield:

: 123-15-9
2-methylvaleraldehyde

: 72522-81-7
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: NH₄Cl, conc NH₃ aq / H₂O / 2 h / 0 - 20 °C

2: conc. HCl / 15 h / Heating

3: 50 percent / acetic acid / 0.08 h / Heating

4: 12.2 g / NaOH, Aspergillus acylase, CoCl₂ / H₂O / 120 h / 37 °C / pH=6.5

5: 63 percent / 2N HCl / 2 h / Heating

6: 82 percent / NaNO₂, 1.5N H₂SO₄ / H₂O / 1.) 0-5 deg C, 1 h; 2.) 0-30 deg C, 2 h

7: 56 percent / LAH / diethyl ether / 1.) 0-5 deg C, 1 h; 2.) RT, 1 h

8: 1.) 30percent HBr; 2.) NaOMe / 1.) H₂O, a.) 0-5 deg C, 10 min; b.) RT, 1 h; 2.) MeOH, RT, 1 h

9: 1.) Li, CuI / 1.) ether, -30 to -20 deg C; 2.) ether, a.) -28 to -18 deg C, b.) -40 to 0 deg C within 4 h

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; Aspergillus acylase; sulfuric acid; hydrogen bromide; sodium methylate; lithium; ammonium chloride; sodium nitrite; In diethyl ether; water; acetic acid;
DOI:10.1016/0040-4020(80)80113-X

Reference yield:

: 2-Amino-3-methyl-hexanenitrile

: 72522-81-7
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-1-ethyl-2-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: conc. HCl / 15 h / Heating

2: 50 percent / acetic acid / 0.08 h / Heating

3: 12.2 g / NaOH, Aspergillus acylase, CoCl₂ / H₂O / 120 h / 37 °C / pH=6.5

4: 63 percent / 2N HCl / 2 h / Heating

5: 82 percent / NaNO₂, 1.5N H₂SO₄ / H₂O / 1.) 0-5 deg C, 1 h; 2.) 0-30 deg C, 2 h

6: 56 percent / LAH / diethyl ether / 1.) 0-5 deg C, 1 h; 2.) RT, 1 h

7: 1.) 30percent HBr; 2.) NaOMe / 1.) H₂O, a.) 0-5 deg C, 10 min; b.) RT, 1 h; 2.) MeOH, RT, 1 h

8: 1.) Li, CuI / 1.) ether, -30 to -20 deg C; 2.) ether, a.) -28 to -18 deg C, b.) -40 to 0 deg C within 4 h

With hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; Aspergillus acylase; sulfuric acid; hydrogen bromide; sodium methylate; lithium; sodium nitrite; In diethyl ether; water; acetic acid;
DOI:10.1016/0040-4020(80)80113-X