N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide

Base Information

• Chemical Name: N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide
• CAS No.: 1138161-42-8
• Molecular Formula: C₃₂H₃₈N₂O₃SSi
• Molecular Weight: 558.817

Synonyms:N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide

Chemical Property of N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide

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Technology Process of N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide

There total 1 articles about N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H40N2O4SSi (1138161-58-6) → N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide (1138161-42-8)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1002/anie.200804138

Reference yield: 96.0%

N-{L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester (1138161-41-7) + N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide (1138161-42-8) → N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester (1138161-43-9)

Guidance literature:

With 2,6-dimethylpyridine; Hg(OTf)2; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1002/anie.200804138

Reference yield: 77.0%

N-{L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester (1138161-41-7) + N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide (1138161-42-8) → N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester (1138161-43-9) + C32H38N2O4Si

Guidance literature:

With mercuric triflate; triethylamine; In acetonitrile; Reagent/catalyst; Solvent;

DOI:10.1021/acs.joc.8b00045

upstream raw materials:

C₃₂H₄₀N₂O₄SSi

Downstream raw materials:

N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

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