Carbamic acid, [1,1-bis(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [1,1-bis(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester
CAS No.:364631-69-6
Molecular Formula:C₁₀H₁₇NO₄
Molecular Weight:215.249
Hs Code.:
Mol file:364631-69-6.mol

Synonyms:Carbamic acid, [1,1-bis(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester

Suppliers and Price of Carbamic acid, [1,1-bis(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [1,1-bis(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：78.79000
LogP:0.25860

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [1,1-bis(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester

There total 7 articles about Carbamic acid, [1,1-bis(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 364631-74-3
5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine

: 364631-69-6
(1,1-bis-hydroxymethyl-prop-2-ynyl)-carbamic acid tert-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(01)00545-2

Reference yield:

: 502183-34-8
(1,1-bis(acetyloxymethyl)prop-2-ynyl)carbamic acid tert-butyl ester

: 364631-69-6
(1,1-bis-hydroxymethyl-prop-2-ynyl)-carbamic acid tert-butyl ester

: 502183-35-9
(S)-(1-acetyloxymethyl-1-hydroxymethylprop-2-ynyl)carbamic acid tert-butyl ester

Guidance literature:: With phosphate buffer; pig liver esterase; In acetonitrile; at 20 ℃; for 3h; pH=6.5;
DOI:10.1021/jo020532t

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 364631-69-6
(1,1-bis-hydroxymethyl-prop-2-ynyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 82 percent / NaHCO₃ / tetrahydrofuran; H₂O / 18 h / 20 °C

2.1: 85 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 2.75 h / -78 °C

3.1: LDA / tetrahydrofuran / 0.75 h / -78 °C

3.2: tetrahydrofuran / 1 h / -78 °C

4.1: Et₃N / CH₂Cl₂ / 18 h / 20 °C

5.1: 24.40 mmol / MeLi / diethyl ether; tetrahydrofuran / -51 - 0 °C

6.1: 100 percent / p-TsOH*H₂O / methanol / 12 h / 20 °C

With oxalyl dichloride; methyllithium; sodium hydrogencarbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4020(01)00545-2