Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

Base Information

Chemical Name:Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester
CAS No.:850559-70-5
Molecular Formula:C₂₈H₃₀N₂O₇
Molecular Weight:506.555
Hs Code.:

Synonyms:Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

Suppliers and Price of Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

There total 9 articles about Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (2R,3S)-3-[2-amino-5-(2-methoxy-ethoxymethoxy)-phenyl]-3-benzyloxycarbonylamino-2-(toluene-4-sulfonyloxy)-propyl ester

: 850559-70-5
Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 55 ℃; for 24h;
DOI:10.1002/anie.200462298

Reference yield:

: 654644-18-5
5-((2-methoxy)ethoxymethoxy)-2-nitrobenzaldehyde

: 850559-70-5
Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 94 percent / tetrahydrofuran / 6 h / 0 °C

2.1: 79 percent / NaOH; t-butyl hypochlorite; (DHQ)2PHAL / potassium osmate dihydrate / propan-1-ol; H₂O / 2 h / 0 °C

3.1: 70 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

4.1: 88 percent / pyridine / CH₂Cl₂ / 2 h / -25 °C

5.1: 87 percent / DMAP / CH₂Cl₂ / 24 h / 20 °C

6.1: H₂ / Lindlar catalyst / tetrahydrofuran / atmospheric pressure

7.1: 532 mg / K₂CO₃ / tetrahydrofuran / 24 h / 55 °C

With pyridine; dmap; sodium hydroxide; lithium borohydride; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; hydrogen; sodium hydride; potassium carbonate; potassium osmate(VI); Lindlar's catalyst; In tetrahydrofuran; propan-1-ol; dichloromethane; water; 2.1: Sharpless aminohydroxylation;
DOI:10.1002/anie.200462298

Reference yield:

: 654644-19-6
(E)-3-[5-(2-Methoxy-ethoxymethoxy)-2-nitro-phenyl]-acrylic acid ethyl ester

: 850559-70-5
Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / NaOH; t-butyl hypochlorite; (DHQ)2PHAL / potassium osmate dihydrate / propan-1-ol; H₂O / 2 h / 0 °C

2: 70 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

3: 88 percent / pyridine / CH₂Cl₂ / 2 h / -25 °C

4: 87 percent / DMAP / CH₂Cl₂ / 24 h / 20 °C

5: H₂ / Lindlar catalyst / tetrahydrofuran / atmospheric pressure

6: 532 mg / K₂CO₃ / tetrahydrofuran / 24 h / 55 °C

With pyridine; dmap; sodium hydroxide; lithium borohydride; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; hydrogen; potassium carbonate; potassium osmate(VI); Lindlar's catalyst; In tetrahydrofuran; propan-1-ol; dichloromethane; water; 1: Sharpless aminohydroxylation;
DOI:10.1002/anie.200462298