Technology Process of Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester
There total 9 articles about Benzoic acid (2S,3S)-3-benzyloxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-2,3-dihydro-1H-indol-2-ylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
tetrahydrofuran;
at 55 ℃;
for 24h;
DOI:10.1002/anie.200462298
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 94 percent / tetrahydrofuran / 6 h / 0 °C
2.1: 79 percent / NaOH; t-butyl hypochlorite; (DHQ)2PHAL / potassium osmate dihydrate / propan-1-ol; H2O / 2 h / 0 °C
3.1: 70 percent / LiBH4 / tetrahydrofuran / 0 - 20 °C
4.1: 88 percent / pyridine / CH2Cl2 / 2 h / -25 °C
5.1: 87 percent / DMAP / CH2Cl2 / 24 h / 20 °C
6.1: H2 / Lindlar catalyst / tetrahydrofuran / atmospheric pressure
7.1: 532 mg / K2CO3 / tetrahydrofuran / 24 h / 55 °C
With
pyridine; dmap; sodium hydroxide; lithium borohydride; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; hydrogen; sodium hydride; potassium carbonate;
potassium osmate(VI); Lindlar's catalyst;
In
tetrahydrofuran; propan-1-ol; dichloromethane; water;
2.1: Sharpless aminohydroxylation;
DOI:10.1002/anie.200462298
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 79 percent / NaOH; t-butyl hypochlorite; (DHQ)2PHAL / potassium osmate dihydrate / propan-1-ol; H2O / 2 h / 0 °C
2: 70 percent / LiBH4 / tetrahydrofuran / 0 - 20 °C
3: 88 percent / pyridine / CH2Cl2 / 2 h / -25 °C
4: 87 percent / DMAP / CH2Cl2 / 24 h / 20 °C
5: H2 / Lindlar catalyst / tetrahydrofuran / atmospheric pressure
6: 532 mg / K2CO3 / tetrahydrofuran / 24 h / 55 °C
With
pyridine; dmap; sodium hydroxide; lithium borohydride; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; hydrogen; potassium carbonate;
potassium osmate(VI); Lindlar's catalyst;
In
tetrahydrofuran; propan-1-ol; dichloromethane; water;
1: Sharpless aminohydroxylation;
DOI:10.1002/anie.200462298
![Benzoic acid (2R,3S)-3-[2-amino-5-(2-methoxy-ethoxymethoxy)-phenyl]-3-benzyloxycarbonylamino-2-(toluene-4-sulfonyloxy)-propyl ester](/Databaselist/images/loading.webp)
