2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide

Base Information

Chemical Name:2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide
CAS No.:1416334-91-2
Molecular Formula:C₂₅H₂₆F₂N₆O₄S
Molecular Weight:544.582
Hs Code.:

Synonyms:2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide

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Chemical Property of 2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide

Chemical Property:

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Technology Process of 2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide

There total 5 articles about 2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1368056-47-6
5-bromo-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-amine

: 1416334-91-2
2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 4h;

Reference yield:

: 152684-30-5
5-bromo-2-methoxy-3-nitropyridine

: 1416334-91-2
2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate / acetic anhydride / 3 h / Reflux

2: pyridine / 20 h / 20 °C

3: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux; Inert atmosphere

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

With pyridine; tin(II) chloride dihdyrate; potassium acetate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetic anhydride; 3: Suzuki Coupling / 4: Suzuki Coupling;

Reference yield:

: 884495-39-0
5-bromo-2-(methyloxy)-3-pyridinamine

: 1416334-91-2
2,4-difluoro-N-[2-(methyloxy)-5-(2-{[2-(4-morpholinyl)ethyl]amino}-1H-benzimidazol-5-yl)-3-pyridinyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 h / 20 °C

2: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux; Inert atmosphere

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

With pyridine; potassium acetate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; 2: Suzuki Coupling / 3: Suzuki Coupling;