ETHYL 4-METHYL-2-PYRIDIN-3-YL-1,3-THIAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 4-METHYL-2-PYRIDIN-3-YL-1,3-THIAZOLE-5-CARBOXYLATE
• CAS No.: 39091-00-4
• Molecular Formula: C₁₂H₁₂N₂O₂S
• Molecular Weight: 248.305
• Hs Code.: 2934100090
• Mol file: 39091-00-4.mol

Synonyms:4-Methyl-2-(pyridin-3-yl)thiazole-5-carboxylicacid ethyl ester

Chemical Property of ETHYL 4-METHYL-2-PYRIDIN-3-YL-1,3-THIAZOLE-5-CARBOXYLATE

Chemical Property:

• Melting Point: 82-84°
• PSA: 80.32000
• LogP: 2.69020
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4-methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 4-methyl-2-(3-pyridyl)thiazole-5-carboxylate is used as a catalytic agent and petrochemical additive.

Technology Process of ETHYL 4-METHYL-2-PYRIDIN-3-YL-1,3-THIAZOLE-5-CARBOXYLATE

There total 3 articles about ETHYL 4-METHYL-2-PYRIDIN-3-YL-1,3-THIAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

thionicotinamide (4621-66-3) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylate (39091-00-4)

Guidance literature:

In ethanol; for 5h; Reflux;

DOI:10.1016/j.bmcl.2016.05.093

Reference yield:

nicotinamide (98-92-0,1255150-40-3) → ethyl 4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylate (39091-00-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetraphosphorus decasulfide / pyridine / 6 h / Reflux

2: ethanol / 5 h / Reflux

With tetraphosphorus decasulfide; In pyridine; ethanol; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.bmcl.2016.05.093

Reference yield:

→ ethyl 4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylate (39091-00-4)

Guidance literature:

Thionicotinsaeureamid,α-Chloracetessigsaeureester;

upstream raw materials:

thionicotinamide

ethyl 2-chloro-3-oxo-butyrate

nicotinamide

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