N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

Base Information

Chemical Name:N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide
CAS No.:317373-84-5
Molecular Formula:C₃₁H₄₂Br₂Cl₂N₂O₄
Molecular Weight:737.399
Hs Code.:

N<sup>1</sup>,N<sup>3</sup>-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

Synonyms:N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

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Technology Process of N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

There total 3 articles about N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 317373-80-1
N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-hydroxyethyl}-2,2-dithylmalonamide

: 317373-84-5
N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

Guidance literature:: With bis(trichloromethyl) carbonate; triphenylphosphine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/ejoc.200600827

Reference yield:

: 317373-77-6
2,2-diethyl-N¹,N³-bis[(R)-2-hydroxy-1-(4-hydroxyphenyl)ethyl]malonamide

: 317373-84-5
N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / K₂CO₃ / acetonitrile / 18 h / Heating

2: 73 percent / triphosgene; triphenylphosphane / CH₂Cl₂ / 1 h / 20 °C

With bis(trichloromethyl) carbonate; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1002/ejoc.200600827

Reference yield:

: 600738-27-0
N₁,N₃-di{(1R)-1-[4-(benzyloxy)phenyl]-2-hydroxyethyl}-2,2-diethylmanonamide

: 317373-84-5
N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / H₂ / Pd/C / methanol / 18 h / 20 °C / 3750.38 Torr

2: 64 percent / K₂CO₃ / acetonitrile / 18 h / Heating

3: 73 percent / triphosgene; triphenylphosphane / CH₂Cl₂ / 1 h / 20 °C

With bis(trichloromethyl) carbonate; hydrogen; potassium carbonate; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.200600827