C₂₀H₁₄BrF₂NO₆

Base Information

• Chemical Name: C₂₀H₁₄BrF₂NO₆
• CAS No.: 1449688-66-7
• Molecular Formula: C₂₀H₁₄BrF₂NO₆
• Molecular Weight: 482.235
• Mol file: 1449688-66-7.mol

Synonyms:C₂₀H₁₄BrF₂NO₆

Chemical Property of C₂₀H₁₄BrF₂NO₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₄BrF₂NO₆

There total 4 articles about C₂₀H₁₄BrF₂NO₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

8-amino-6-bromo-4-oxo-4H-chromene-2-carboxylic acid ethyl ester (156904-82-4) + 2,6-difluoro-4-methoxybenzoyl chloride (125369-56-4) → C20H14BrF2NO6 (1449688-66-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jm4009373

Reference yield:

5'-bromo-2'-hydroxy-3'-nitroacetophenone (70978-54-0) → C20H14BrF2NO6 (1449688-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 5 °C / Inert atmosphere

1.2: Cooling with ice; Reflux

2.1: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 0.33 h / 65 - 70 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dichloromethane / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm4009373

Reference yield:

ethyl 6-bromo-8-nitro-4-oxo-4H-chromene-2-carboxylate → C20H14BrF2NO6 (1449688-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 0.33 h / 65 - 70 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dichloromethane / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jm4009373

upstream raw materials:

5'-bromo-2'-hydroxy-3'-nitroacetophenone

8-amino-6-bromo-4-oxo-4H-chromene-2-carboxylic acid ethyl ester

2,6-difluoro-4-methoxybenzoyl chloride

2,6-difluoro-4-methoxybenzoic acid

Downstream raw materials:

C₁₈H₁₀BrF₂NO₆

Refernces