70978-54-0

Usage

Uses

Used in Chemical Synthesis:
5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE is used as a chemical reagent for the synthesis of amides and benzoxazoles. It facilitates the direct synthesis process using a sulfate catalyst and microwaves, which enhances the efficiency and yield of the target compounds.
Used in Pharmaceutical Research:
In the field of pharmaceutical research, 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE is utilized in studies involving HIV-1 integrase inhibitors. Its unique structure allows it to be a potential candidate for the development of new antiviral agents, specifically targeting the integrase enzyme responsible for the integration of the viral genome into the host's DNA.
Used in Organic Chemistry:
5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE is also employed in various organic chemistry applications, such as the synthesis of complex organic molecules and the development of new synthetic routes. Its reactivity and functional groups make it a valuable intermediate in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.

Preparation

Preparation by nitration of 5-bromo-2-hydroxyacetophenone in refluxing carbon tetrachloride (88%).

Upstream product

• 1450-75-5 5-Bromo-2-hydroxyacetophenone 

Downstream Products

• 70977-85-4 1-(2-hydroxy-3-amino-5-bromophenyl)ethan-1-one 
• 671779-99-0 1-nitro-2,3-dihydroxy-5-bromobenzene 
• 944355-71-9 4-bromo-2-(1-hydroxyethyl)-6-nitrophenol 
• 70977-72-9 3'-Amino-2'-hydroxyacetophenone 
• 474554-55-7 1-(5-bromo-2-methoxy-3-nitrophenyl)-1-ethanone 
• 70977-97-8 1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 3-acetyl-5-bromo-2-hydroxy-anilide 
• 70977-47-8 1H-tetrazole-5-carboxylic acid 3-acetyl-5-bromo-2-hydroxy-anilide 
• 1448010-29-4 1-(2-hydroxy-5-(6-methoxynaphthalen-2-yl)-3-nitrophenyl)ethanone 
• 1441772-25-3 6-bromo-3-hydroxy-8-nitro-2-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 1441774-65-7 C₁₈H₁₆BrNO₇ 
• 1449688-66-7 C₂₀H₁₄BrF₂NO₆ 
• 1449688-65-6 C₂₀H₁₅BrFNO₆ 
• 1449688-64-5 C₂₀H₁₅BrFNO₆ 
• 1449688-72-5 C₁₈H₁₀BrF₂NO₆ 

Relevant academic research and scientific papers

ANTI-INFECTIVE AGENTS

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

2-IMINOPYRROLIDINE DERIVATES

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101 - R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, -CH2-, etc.; Y2 represents a single bond, -CO-, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.

Benzopyran derivatives having leukotriene-antagonistic action

The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are characterized by good oral adsorption. The compounds of the present invention may be used as anti-inflammatory and antiallergic medicaments, and in the treatment of cardiovascular diseases.

Substituted alkylaryl ketones and methods of use as herbicides

Ring and side chain substituted alkylaryl ketones are useful in controlling the growth of germinating and seedling weed grasses and germinating and seedling broadleaf weeds.