2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone

Base Information

Chemical Name:2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone
CAS No.:150208-62-1
Molecular Formula:C₁₅H₁₈Cl₂N₂O
Molecular Weight:313.227
Hs Code.:

Synonyms:2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone

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Chemical Property of 2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone

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Technology Process of 2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone

There total 5 articles about 2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 93643-24-4
(S)-octahydropyrrolo[1,2-a]pyrazine

: 150208-62-1
2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm00068a007

Reference yield:

: 15761-39-4
N-Boc-L-proline

: 150208-62-1
2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, HOBT monohydrate, Et₃N / 24 h / Ambient temperature

2: 100 percent / 1 h / Ambient temperature

3: 65 percent / Et₃N / methanol / Heating

4: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

5: 94 percent / DCC / CH₂Cl₂

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00068a007

Reference yield:

: (S)-(-)-N-(tert-butoxycarbonyl)prolylglycine methyl ester

: 150208-62-1
2-(3,4-Dichloro-phenyl)-1-(R)-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 1 h / Ambient temperature

2: 65 percent / Et₃N / methanol / Heating

3: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

4: 94 percent / DCC / CH₂Cl₂

With lithium aluminium tetrahydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00068a007