C₃₄H₃₅N₃O₇

Base Information

• Chemical Name: C₃₄H₃₅N₃O₇
• CAS No.: 1300590-75-3
• Molecular Formula: C₃₄H₃₅N₃O₇
• Molecular Weight: 597.668
• Mol file: 1300590-75-3.mol

Synonyms:C₃₄H₃₅N₃O₇

Chemical Property of C₃₄H₃₅N₃O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₃₅N₃O₇

There total 14 articles about C₃₄H₃₅N₃O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C33H33N3O7 (1300590-73-1) + methyl iodide (74-88-4) → C34H35N3O7 (1300590-75-3)

Guidance literature:

C₃₃H₃₃N₃O₇; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere; Cooling with acetone-dry ice;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Cooling with acetone-dry ice;

Reference yield:

C33H33N3O7 (1300590-73-1) → C34H35N3O7 (1300590-75-3)

Guidance literature:

C₃₃H₃₃N₃O₇; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

methyl halide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

DOI:10.1039/c5ob00242g

Reference yield:

((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol (153186-10-8) → C34H35N3O7 (1300590-75-3)

Guidance literature:

Multi-step reaction with 14 steps

1.1: dmap; triethylamine / dichloromethane / 20 h / Inert atmosphere; Cooling; Reflux

2.1: sulfuric acid; acetic acid / 3.5 h

3.1: N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere; Reflux

4.1: methylamine / water; tetrahydrofuran / 0.5 h / 20 °C

5.1: dmap; trifluoromethane sulfonyl chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

6.1: sodium hydroxide; water / tetrahydrofuran / 1.5 h / 20 °C

7.1: pyridine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

8.1: sodium azide / N,N-dimethyl-formamide / 48 h / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12.5 h / Inert atmosphere

10.1: dipyridinium dichromate / N,N-dimethyl-formamide / 4.5 h / 20 °C / Inert atmosphere; Molecular sieve

10.2: 1 h

11.1: water; tributylphosphine / tetrahydrofuran / 3.5 h / 20 °C

12.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 21.5 h / 20 °C / Inert atmosphere; Cooling with ice

13.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere; Cooling with ice

13.2: 0.5 h / Cooling with ice

14.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with acetone-dry ice

14.2: 0.5 h / 20 °C / Cooling with acetone-dry ice

With pyridine; dmap; dipyridinium dichromate; sodium azide; N,O-bis-(trimethylsilyl)-acetamide; tributylphosphine; trifluoromethane sulfonyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tetrabutyl ammonium fluoride; water; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; methylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

C₃₃H₃₃N₃O₇

methyl iodide

((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol

C₄₀H₄₆O₈Si

Downstream raw materials:

C₃₃H₃₃N₃O₈

N₂'-methyl-2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine