Imidazo[1,2-a]pyridin-8(5H)-one, 6,7-dihydro-2-methyl- (9CI)

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-8(5H)-one, 6,7-dihydro-2-methyl- (9CI)
• CAS No.: 363607-99-2
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• Mol file: 363607-99-2.mol

Synonyms:2-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-8-one;2-Methyl-6,7-dihydro-5H-imidazo[1,2-a]pyridin-8-one

Chemical Property of Imidazo[1,2-a]pyridin-8(5H)-one, 6,7-dihydro-2-methyl- (9CI)

Chemical Property:

• PSA: 34.89000
• LogP: 1.16800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Imidazo[1,2-a]pyridin-8(5H)-one, 6,7-dihydro-2-methyl- (9CI)

There total 2 articles about Imidazo[1,2-a]pyridin-8(5H)-one, 6,7-dihydro-2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridine (79707-53-2) → 2-Methyl-6,7-dihydro-5H-imidazo[1,2-a]pyridin-8-one (363607-99-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 70 ℃; under 41254.1 Torr;

Reference yield:

→ 2-Methyl-6,7-dihydro-5H-imidazo[1,2-a]pyridin-8-one (363607-99-2)

Guidance literature:

Reference yield: 97.0%

(2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester (363599-28-4) + 2-Methyl-6,7-dihydro-5H-imidazo[1,2-a]pyridin-8-one (363607-99-2) → (8R,9R)-8-(tert-butyidimethylsilanyloxy)-2-methyl-9-phenyl-5,6,7,8,9,10-hexahydro-imidazo-[1,2-h][1,7]naphthyridin-7-one (419566-17-9)

Guidance literature:

(2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester; 2-Methyl-6,7-dihydro-5H-imidazo[1,2-a]pyridin-8-one; With toluene-4-sulfonic acid; In water; toluene; for 1.5h; Heating / reflux;

With lithium diisopropyl amide; In tetrahydrofuran; at -25 - 20 ℃; for 1h;

upstream raw materials:

2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridine

Downstream raw materials:

(8R,9R)-8-(tert-butyidimethylsilanyloxy)-2-methyl-9-phenyl-5,6,7,8,9,10-hexahydro-imidazo-[1,2-h][1,7]naphthyridin-7-one