(2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester

Base Information

• Chemical Name: (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester
• CAS No.: 363599-28-4
• Molecular Formula: C₁₇H₂₉NO₃Si
• Molecular Weight: 323.508
• Mol file: 363599-28-4.mol

Synonyms:(2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester

Chemical Property of (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester

There total 1 articles about (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R)-ethyl 3-amino-2-hydroxy-3-phenylpropanoate (481054-47-1) + tert-butyldimethylsilyl chloride (18162-48-6) → (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester (363599-28-4)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 97.0%

(2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester (363599-28-4) + 2-Methyl-6,7-dihydro-5H-imidazo[1,2-a]pyridin-8-one (363607-99-2) → (8R,9R)-8-(tert-butyidimethylsilanyloxy)-2-methyl-9-phenyl-5,6,7,8,9,10-hexahydro-imidazo-[1,2-h][1,7]naphthyridin-7-one (419566-17-9)

Guidance literature:

(2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester; 2-Methyl-6,7-dihydro-5H-imidazo[1,2-a]pyridin-8-one; With toluene-4-sulfonic acid; In water; toluene; for 1.5h; Heating / reflux;

With lithium diisopropyl amide; In tetrahydrofuran; at -25 - 20 ℃; for 1h;

Reference yield: 64.0%

4,5,6,7-tetrahydro-2,3-dimethyl-7-oxo-3H-benzoimidazole-5-carboxylic acid methylamide (871724-25-3) + (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester (363599-28-4) → (7R,8R)-[4,5,6,7,8,9-hexahydro-7-hydroxy-2,3-dimethyl-6-oxo-8-phenyl-3H-imidazo[4,5-h]quinoline-5-yl]-carboxylic acid methylamide (871724-28-6)

Guidance literature:

4,5,6,7-tetrahydro-2,3-dimethyl-7-oxo-3H-benzoimidazole-5-carboxylic acid methylamide; (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid ethyl ester; In 2-methoxy-ethanol; at 150 ℃; for 96h;

With water; sodium hydrogencarbonate; In dichloromethane;

upstream raw materials:

(2R,3R)-ethyl 3-amino-2-hydroxy-3-phenylpropanoate

tert-butyldimethylsilyl chloride

Downstream raw materials:

(7R,8R)-7-hydroxy-2,3-dimethyl-8-phenyl-5,7,8,9-tetrahydro-3H,4H-imidazo[4,5-h]quinolin-6-one

(7R,8R)-7-(tert-butyl-dimethyl-silanyloxy)-2,3-dimethyl-8-phenyl-5,7,8,9-tetrahydro-3H,4H-imidazo[4,5-h]quinolin-6-one

(7R,8R)-[4,5,6,7,8,9-hexahydro-7-hydroxy-2,3-dimethyl-6-oxo-8-phenyl-3H-imidazo[4,5-h]quinoline-5-yl]-carboxylic acid methylamide

(8R,9R)-8-(tert-butyidimethylsilanyloxy)-2-methyl-9-phenyl-5,6,7,8,9,10-hexahydro-imidazo-[1,2-h][1,7]naphthyridin-7-one