Technology Process of N-acetyl-3-(4-methoxyphenyl)-3-methyl-6-nitroindoline
There total 7 articles about N-acetyl-3-(4-methoxyphenyl)-3-methyl-6-nitroindoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iron(III) chloride;
In
dichloromethane;
at 20 ℃;
for 12h;
regioselective reaction;
DOI:10.1002/chem.201400284
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate / 0.5 h / 0 - 20 °C
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; sulfolane / 1 h / 100 °C
3: sodium cyanoborohydride / 2 h / 100 °C
4: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 2.5 h / 20 °C
5: iron(III) chloride / dichloromethane / 12 h / 20 °C
With
iron(III) chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium cyanoborohydride; toluene-4-sulfonic acid; sodium hydroxide; trichlorophosphate;
In
sulfolane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201400284
- Guidance literature:
-
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; sulfolane / 1 h / 100 °C
2: sodium cyanoborohydride / 2 h / 100 °C
3: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 2.5 h / 20 °C
4: iron(III) chloride / dichloromethane / 12 h / 20 °C
With
iron(III) chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium cyanoborohydride; toluene-4-sulfonic acid; sodium hydroxide;
In
sulfolane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201400284