N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide

Base Information

• Chemical Name: N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide
• CAS No.: 885328-56-3
• Molecular Formula: C₆₆H₁₀₄N₆O₁₈S₂
• Molecular Weight: 1333.71
• Mol file: 885328-56-3.mol

Synonyms:N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide

Chemical Property of N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide

There total 1 articles about N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propionic acid + bis(4-aminophenyl)disulfide (722-27-0) → N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide (885328-56-3)

Guidance literature:

(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propionic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; dimethyl sulfoxide; at 20 ℃;

bis(4-aminophenyl)disulfide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/ol053049o

Reference yield:

N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide (885328-56-3) + sodium methansulfinate (20277-69-4) → methanesulfonothioic acid S-[4-[(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanylamino]phenyl] ester (885328-58-5)

Guidance literature:

With iodine; In dichloromethane; at 20 ℃;

DOI:10.1021/ol053049o

Reference yield:

N,N'-dithiodi(4,1-phenylene)bis-(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanamide (885328-56-3) → {[(S)-2-(Bis-carboxymethyl-amino)-1-(4-methanesulfonylsulfanyl-phenylcarbamoyl)-ethyl]-carboxymethyl-amino}-acetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: I₂ / CH₂Cl₂ / 20 °C

2: 106 mg / formic acid / 48 h / 20 °C

With formic acid; iodine; In dichloromethane;

DOI:10.1021/ol053049o

upstream raw materials:

bis(4-aminophenyl)disulfide

Downstream raw materials:

methanesulfonothioic acid S-[4-[(S)-2,3-bis[di(tert-butoxycarbonylmethyl)amino]propanylamino]phenyl] ester