5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine
• CAS No.: 1542260-44-5
• Molecular Formula: C₃₇H₃₅N₃O₈
• Molecular Weight: 654.66

Synonyms:5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

Chemical Property of 5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

There total 7 articles about 5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.08%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N4-benzoyl-cytidine (1542260-41-2) → 5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N4-benzoyl-cytidine (1542260-44-5)

Guidance literature:

With pyridine; for 4h;

Reference yield:

1-O-methyl-α/β-2,3,4,5,5′-pentadeuterium-D-ribofuranoside → 5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N4-benzoyl-cytidine (1542260-44-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 48 h / 0 - 4 °C

2.1: hydrogen bromide / acetic acid / 0.5 h / 20 °C

3.1: pyridine / chloroform / 72 h / 20 °C

4.1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium sulfate / 15 h / Reflux

4.2: 0.25 h / 40 °C

4.3: 2.5 h / Reflux

5.1: water; sodium hydroxide; pyridine / methanol / 0.33 h / 0 °C

6.1: pyridine / 4 h

With pyridine; ammonium sulfate; water; hydrogen bromide; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In methanol; dichloromethane; chloroform; acetic acid;

Reference yield:

methyl ribofuranoside (1824-96-0,1824-97-1,3795-68-4,3795-69-5,4229-54-3,5531-18-0,7473-45-2,13039-63-9,13039-64-0,13039-65-1,13039-67-3,22416-73-5,22861-09-2,25129-51-5,52485-92-4,52689-55-1,52689-56-2,56607-40-0,72880-70-7,79083-42-4,86782-30-1,86782-31-2,89615-03-2,89673-67-6,89707-99-3,102045-32-9,135910-17-7) → 5'-O-dimethoxytrityl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N4-benzoyl-cytidine (1542260-44-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: water-d2 / 168 h / 110 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 48 h / 0 - 4 °C

3.1: hydrogen bromide / acetic acid / 0.5 h / 20 °C

4.1: pyridine / chloroform / 72 h / 20 °C

5.1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium sulfate / 15 h / Reflux

5.2: 0.25 h / 40 °C

5.3: 2.5 h / Reflux

6.1: water; sodium hydroxide; pyridine / methanol / 0.33 h / 0 °C

7.1: pyridine / 4 h

With pyridine; ammonium sulfate; water; hydrogen bromide; water-d2; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In methanol; dichloromethane; chloroform; acetic acid;

upstream raw materials:

4,4'-dimethoxytrityl chloride

2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

methyl ribofuranoside

2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoylcytidine

Downstream raw materials:

5′-O-dimethoxytrityl-2′-O-terbutyldimethylsilyl-3′-O-succinyl pyridinium salt-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoylcytidine

5'-O-dimethoxytrityl-3'-O-terbutyldimethylsilyl-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-N,N-diisopropyl-O-(2-cyanoethyl)phosphoramidite-2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

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